Modification of Radiosensitivity of Biological Systems
ثبت نشده
چکیده
Radiotherapy is the most common treatment of cancer. It is also practised in combination with chemotherapy or immunotherapy. Although many cases are successfully treated, failures in local control do occur and even a modest improvement in the relative radiosensitivity of tumour cells would result in a substantial therapeutic gain. In addition, the presently practised fractionated dose schedule for cancer treatment usually extends over a long period causing hardships and economic difficulties to patients in developing countries who often have to travel long distances for their treatment. It would therefore be desirable to shorten the period of treatment. Radiosensitizers offer some hope in these directions.
منابع مشابه
Assessment of in vitro radiosensitivity parameters of breast cancer cells following exposure to radiotherapy hospital-based facilities
Introduction: The aim of the present study was to assess the radiosensitivity parameters for SK-BR-3 (SKBR3) breast cancer cells that could be implemented in the cutting-edge treatment planning systems (TPS) for accelerated partial-breast irradiation (APBI). Materials and Methods: The cell survival fraction and its relevant radiosensitivity coefficients, namely α and β, in linear-quadratic (LQ)...
متن کاملRadiosensitivity Study for Identifying the Lethal Dose in MR219 (Oryza sativa L. spp. Indica cv. MR219)
The purpose of the research was determine the effects of gamma ray on seed germination, seedling height and root length of Rice (Oryza sativa L. spp. Indica cv. MR219) to identify the Lethal Dosage of the radiation. Paddy seeds of MR219 were exposed to different doses of gamma radiations viz 50,100,150,200,250,300,350,400,450,500,600,700,800,900 and 1000 Gy using 60Co as the radiation source. T...
متن کاملIs Radiosensitivity Associated to Different Types of Blood Groups? (A cytogenetic study)
Many biological factors affect radiosensitivity. In this study, radiosensitivity among the different blood groups was investigated. Peripheral blood sample of 95 healthy people were divided into two parts. One part was irradiated with 2 Gy Co-60 gamma rays and the second one was considered as control. Then all the samples were studied by cytokinesis-blocked micronucleus assay (CBMN assay). Our ...
متن کاملRadioresponse of human lymphocytes pretreated with boron and gadolinium as assessed by the comet assay
Background: Boron and gadolinium are among the nuclides that hold a unique property of being a neutron capture therapy agent. Neutron beams have often a considerable portion of gamma rays with fast neutrons. Gamma rays, as beam contaminants, can cause considerable damage to normal tissues even if such tissues do contain high boron concentrations. Materials and Methods: The modification of radio...
متن کاملTumour radiobiology beyond fractionation
Historically it has been shown repeatedly that single high doses of radiation do not allow a therapeutic differential between tumor and critical normal tissues but dose fractionation does. The purpose of conventional dose fractionation is to increase dose to the tumor while preserving normal tissue function. Tumors are generally irradiated with 2Gy dose per fraction delivered daily to a more or...
متن کامل